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Adaptive immunity
The part of the immune system that builds up responses to antigens or foreign invaders (like viruses or bacteria) as we are exposed to disease or receive a vaccination. This response can become stronger and more specialized over time or with repeated exposure.
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Adeno associated viral (AAV) vector
A type of virus that does not make people feel sick and is used to deliver genetic material into cells, such as DNA or RNA.
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Adenovirus
A type of virus used to deliver small to large DNA packages into cells. Adenoviruses are highly immunogenic (meaning able to produce an immune response) and therefore mostly used for cancer applications.
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Adverse event
Any health problem ranging from minor to serious that happens after receiving a vaccine, treatment, or therapy.
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Allele
Two, or more, sets of genetic sequence present at a particular chromosomal location (locus). One allele is inherited from each parent, and the pair determines the genotype of a given gene.
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Allogeneic
Cells used from someone other than the patient during treatment. A helpful tip to remember this is that "allo" means other.
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Amino acids
The basic building blocks of all proteins, around 20 amino acids make up all animal and plant proteins.
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Antibody
Protein produced by the body to fight infections and foreign antigens.
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Antigens
A piece of a foreign invader that the immune system recognizes as not being part of itself, such as the protein surface of a virus.
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Antisense oligonucleotide (ASO) therapies
Utilize ASOs to interact with mRNA in order to inhibit or alter protein function.
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Antisense oligonucleotides (ASOs)
Synthetic (made in a lab) single strand of genetic material that targets mRNA from a specific gene to either increase to decrease production of the protein encoded by the mRNA.
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Aptamer
Synthetic, single-stranded DNA or RNA that can bind a specific target and can sometimes serve as the chemical equivalent of an antibody.
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Aptamer therapies
Utilizes RNA aptamers that can tightly bind to proteins on the outside of the cell to provide unique therapeutic advantages.
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Autologous
Cells from an individual to be used during a possible cell therapy on that same individual. Auto means "self," so this may also be considered being a "self-donor."
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Autosomal dominant
A pattern of inheriting a genetic change that is located on one of the non-sex, numbered chromosomes (autosomal). A single copy of the disease-associated gene variant from one parent is enough to pass along a disease.
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Autosomal recessive
A pattern of inheriting a genetic change where two copies of a disease associated gene variant (one on each allele) are needed to pass along a disease.
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Autosome
One of the numbered chromosomes; humans have 22 pairs that are numbered 1 to 22. These do not include the sex chromosomes (X or Y).